Reinventing therapeutic antibodies
for the treatment of cancer

Fostering a culture grounded in our vision, mission and values, CytomX is an Xtraordinary clinical-stage biopharmaceutical company with a unique approach to treating cancer and a team dedicated to make a difference. We call this the CytomX Factor. With five clinical-stage ProbodyTM programs expected by the end of 2018, our goal is to reinvent therapeutic antibodies for the treatment of cancer.

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Yes, we can truly make a difference in the lives of patients.

We’re on it.

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Vision

Transforming lives with safer, more effective therapies

Mission

Changing the treatment of cancer by urgently advancing our Probody pipeline

Values

Integrity

We act in an honest, respectful, ethical manner

Commitment

We are dedicated to patients, CytomX, and our teammates

Creativity

Curiosity and innovation have the power to change lives

Teamwork

Together, we will succeed

Accountability

Through open communication, we hold each other to the highest possible standards

Fun

We enjoy working together and celebrating success

Xperienced executive team

CytomX is led by a seasoned executive team with deep experience in the fields of antibody drug development, cancer biology, clinical and translational medicine and business development.

Sean A. McCarthy, D. Phil.

President and Chief Executive Officer
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Dr. McCarthy joined CytomX in December 2010 as our chief business officer and became a member of our board of directors and our president and chief executive officer in August 2011. Dr. McCarthy has more than twenty years of experience in the biotechnology industry encompassing roles in R&D, business development, financing and general management. Following completion of his post-doctoral training at the DNAX Research Institute (now Merck Palo Alto), Dr. McCarthy held research leadership and program management roles at Millennium Pharmaceuticals where he managed biologics discovery programs. From Millennium, Dr. McCarthy joined SGX Pharmaceuticals, where he spearheaded a wide range of large pharma partnerships as vice president business development and helped drive a strategic reorientation of the company from a platform business model to product-focused oncology company, leading to a successful initial public offering in 2006. Immediately prior to joining CytomX, Dr. McCarthy was a transactional partner at Pappas Ventures from April 2006 to December 2010, where he was responsible for investments in therapeutic, medical device and molecular diagnostic companies. Dr. McCarthy is an author on multiple peer reviewed scientific publications, issued patents and filed patent applications. He received a B.Sc. in biochemistry and pharmacology at King’s College, University of London; an MBA from the Rady School of Management at the University of California San Diego; and a D.Phil. in cancer biology from St. John’s College, University of Oxford. Dr. McCarthy currently serves as a member of the Board of Directors of the California Life Sciences Association.

W. Michael Kavanaugh, M.D.

Chief Scientific Officer
and Head of Research
and Non-Clinical Development
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Michael Kavanaugh, M.D. joined CytomX in January 2015 as chief scientific officer and head of research and early development. Prior to joining CytomX, Dr. Kavanaugh was senior vice president and chief scientific officer of Five Prime Therapeutics. Since joining the company in 2009, he held multiple positions in research and development and led the growth of the company’s therapeutic pipeline. Before Five Prime, Dr. Kavanaugh served as vice president of Novartis Vaccines & Diagnostics, Inc. and executive director of Oncology Biologics in the Novartis Institutes of Biomedical Research. He joined Novartis in 2006 as part of the company’s acquisition of the Chiron Corporation, where he was vice president and head of antibody and protein therapeutics research. Dr. Kavanaugh received his medical doctorate from Vanderbilt University and his bachelor’s degree in molecular biochemistry and biophysics from Yale University. He completed training in internal medicine, cardiovascular disease and molecular and cellular biology at the University of California, San Francisco and the Cardiovascular Research Institute. Dr. Kavanaugh also currently serves as an attending staff physician at the San Francisco Veterans Administration Medical Center and as an associate clinical professor of medicine at UCSF.

Rachel Humphrey, M.D.

Chief Medical Officer
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Rachel Humphrey, M.D., joined CytomX in August 2015. Dr. Humphrey recently held positions as vice president and head of immuno-oncology both at Eli Lilly and at AstraZeneca, where she was responsible for building the immuno-oncology departments and supervising the strategies and designs for all immuno-oncology agents in development. She previously served as vice president of product development at Bristol-Myers Squibb, where she led all aspects of clinical development of the antibody therapy Yervoy™ through the submission of global biologics license applications and global launch. At Bayer, Dr. Humphrey supervised all aspects of the early and late stage clinical development of Nexavar for treatment of renal cell carcinoma. She began her career as an oncology fellow and staff physician at the National Cancer Institute. Dr. Humphrey trained in internal medicine at the Johns Hopkins Hospital, received her medical degree from Case Western Reserve University and her bachelor’s degree from Harvard University.

Debanjan Ray

Chief Financial Officer and Head of Corporate Development
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Debanjan Ray joined CytomX in 2011, and serves as chief financial officer and head of corporate development. He previously led partnering activities at CytomX, structuring and executing collaborations with AbbVie, BMS, Immunogen, and Pfizer that have resulted in more than $300 million in upfront and milestone payments to date and total potential deal value in excess of $5 billion. He has 15 years of experience in the biotechnology industry, including strategic consulting, venture capital and business development. Prior to joining CytomX, Mr. Ray was vice president of business development at Itero Biopharmaceuticals, where he helped drive several collaborations, including the company’s partnership on its lead product with Watson Pharmaceuticals. Prior to Itero, Mr. Ray was an associate director of business development at Portola Pharmaceuticals and an associate in the life sciences venture practice at J.P. Morgan Partners. He also served as a business analyst in the healthcare practice at McKinsey & Company. Mr. Ray holds a dual B.S. in chemical engineering and biology from the Massachusetts Institute of Technology and an M.B.A. from The Wharton School, University of Pennsylvania.

Danielle Olander

Senior Vice President, Talent and Administrative Operations
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Danielle Olander has led human resources management and operations for more than 20 years and has been a member of the CytomX team since 2014. Prior to CytomX, she served as the senior director of human resources management at Portola Pharmaceuticals. Prior to joining Portola, Danielle held positions at SuperGen (now Astex Pharmaceuticals), SUGEN (acquired by Pfizer) and Kinetic Search. She received her B.S. in human resource management from Colorado Technical University. She is chairperson of the Biotechnology HR Network and an active member of the Society for Human Resources Management and World at Work, The Total Rewards Association.

Sridhar Viswanathan, Ph.D.

Senior Vice President, Process Sciences and Manufacturing Operations
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Sridhar Viswanathan, Ph.D., is the senior vice president of process sciences and manufacturing operations. Dr. Viswanathan previously served as vice president of process development and manufacturing operations for Perseid Therapeutics, a joint venture between Maxygen and Astellas that was subsequently acquired by Astellas. He was responsible for all internal process development and external manufacturing operations at contract manufacturing organizations for advancing CTLA4-Ig Fc fusion products for autoimmune disease and organ transplant rejection. Before joining Perseid, Dr. Viswanathan spent several years at Maxygen directing process development and clinical manufacturing for next-generation biologics programs, including PEGylated interferon alpha, PEG-G-CSF and FVIIa. Prior to this, he held positions at Coulter Pharmaceutical, Bayer Corporation and Genentech. He received his doctorate in biochemistry from the University of Mississippi Medical Center and completed postdoctoral training at Rockefeller University and Stanford University.

Alison Joly, Ph.D

Senior Vice President, Program and Alliance Management
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Alison Joly, Ph.D., has worked in the biotechnology sector for more than 20 years serving in multiple roles involved in oncology drug discovery, development and commercialization. Prior to joining CytomX in April 2016 as senior vice president, program and alliance management, Dr. Joly spent 14 years at Exelixis, most recently serving as vice president of program management for oncology. She oversaw multiple external partnerships relating to early and mid-stage development assets and played a critical role in the development, approval and launch of COMETRIQTM (cabozantinib) for locally advanced metastatic medullary thyroid carcinoma. Prior to Exelixis, Dr. Joly served as a scientist at Scios and CV Therapeutics. Dr. Joly holds a bachelor of science and a doctorate in biochemistry from The University of Liverpool, U.K., and completed her postdoctoral research at University of Florida and University of California, Los Angeles.

Xemplary Board of Directors

Hoyoung Huh, M.D., Ph.D.

Chairman

Hoyoung Huh, M.D., Ph.D., is the chairman of Geron Corporation, where he has also held executive chairman and director positions, and is on the board of directors for Addex Pharmaceuticals. Dr. Huh has been involved in the formation, management and financing of more than 20 successful entities across the United States, Europe and Asia. He was previously the president, chief executive officer and chairman of BiPar Sciences Inc., which was acquired by Sanofi-Aventis in 2009. Prior to that, he served as the chairman of Epizyme Inc., chief operating officer and board member of Nektar Therapeutics and board member of Facet Biotech, which was acquired by Abbott Laboratories in 2010. Dr. Huh was formerly a partner at McKinsey & Company in the healthcare and technology practices. Dr. Huh holds a B.S. in biochemistry from Dartmouth College, an M.D. from Cornell University Medical College, and a Ph.D. in genetics and cell biology from Cornell University/Sloan-Kettering Institute.

Charles S. Fuchs, M.D., M.P.H.

Director

Charles S. Fuchs, M.D., M.P.H., is an internationally recognized expert in gastrointestinal cancers, cancer epidemiology and cancer drug development, and conducts research assessing novel therapeutic approaches in oncology. Dr. Fuchs is the Richard Sackler and Jonathan Sackler Professor of Medicine, Director of the Yale Cancer Center and Physician-in-Chief of the Smilow Cancer Hospital. He was previously professor of medicine at Harvard Medical School and chief of the gastrointestinal oncology division and the Robert T. and Judith B. Hale Chair in Pancreatic Cancer at Dana-Farber Cancer Institute. Dr. Fuchs received his medical degree from Harvard Medical School in 1986. He completed his medical residency at Brigham and Women’s Hospital, where he also served as chief medical resident, and completed his medical oncology fellowship at Dana-Farber Cancer Institute. In 1994, he received his M.P.H. from Harvard School of Public Health.

Fred Gluck

Director

Fred Gluck is a former managing partner (chief executive) of McKinsey & Company Inc. After retiring from McKinsey in 1995, he joined the Bechtel Group, where he served as vice chairman and director. He later rejoined McKinsey & Company as a consultant until retiring again in July 2003. Mr. Gluck was the founding chairman and CEO of both CytomX and Cynvenio Biosystems and continues to serve as chairman of Cynvenio. He also serves as director of a number of eleemosynary organizations, including the Foundation Board of the University of California, Santa Barbara, the Kavli Institute of Theoretical Physics and The New York Presbyterian Hospital (Emeritus). He recently retired from the Board of Amgen and was the presiding director of HCA (Hospital Corporation of America). Mr. Gluck received his B.S. from Manhattan College and an M.S. from New York University: both degrees in electrical engineering.

Marion McCourt

Director

Ms. McCourt has served as a member of our board of directors since March 2017. Ms. McCourt has served as senior vice president, Commercial of Regeneron Pharmaceuticals, Inc. since February 2018. Prior to joining Regeneron, she served as president and chief operating officer of Axovant Sciences, Inc. from April 2017 to February 2018. Previously, she served as chief operating officer at Medivation from February 2016 until the company’s acquisition by Pfizer in September 2016. Prior to joining Medivation, Ms. McCourt served at Amgen Inc., first as vice president and general manager of Amgen’s Bone Health & Primary Care Business Unit from May 2013 to February 2014 and then as vice president of U.S. commercial operations from February 2014 to January 2016. Before joining Amgen, Ms. McCourt held numerous positions over a twelve-year career at AstraZeneca starting in November 1999, a pharmaceutical and biopharmaceutical company, including most recently serving as chief operating officer of AstraZeneca U.S. from December 2011 to March 2013. Ms. McCourt has served on the board of directors of Scynexis, a publicly-traded pharmaceutical company, since January 2017. Ms. McCourt holds a B.S. degree in Biology from Lafayette College. We believe that Ms. McCourt is qualified to serve on our board of directors due to her operational and commercial leadership experience at several public life sciences companies. Ms. McCourt’s service as a member of the Board will cease at the Annual Meeting scheduled to be held on June 13, 2018.

Matthew Young

Director

Matthew P. Young was appointed executive vice president and chief financial officer of Jazz Pharmaceuticals in February 2015. He previously had served as senior vice president and chief financial officer of Jazz since March 2014 and as senior vice president, corporate development of Jazz since April 2013. Prior to joining Jazz, Mr. Young worked in investment banking for approximately 20 years. From February 2009 to April 2013, he served as a managing director in global healthcare of Barclays Capital Inc., an investment banking firm, where his role included acting as the co-head of life sciences at Barclays Capital. From 2007 to 2008, Mr. Young served as a managing director of Citigroup Global Markets Inc., an investment banking firm, and from 2003 to 2007, as a managing director of Lehman Brothers Inc., an investment banking firm. In 2015, he joined the board of directors of PRA Health Sciences Inc., a contract research company. Mr. Young received a B.S. in economics and a M.B.A. from the Wharton School of the University of Pennsylvania.

John Scarlett, M.D.

Director

John “Chip” A. Scarlett currently serves as chief executive officer, president and a member of the board of directors of Geron Corporation. Since February 2015, Dr. Scarlett has also served as a member of the board of directors of Chiasma, Inc. Prior to joining Geron in 2011, Dr. Scarlett served as president, chief executive officer and a member of the board of directors of Proteolix, Inc., from February 2009 until its acquisition by Onyx Pharmaceuticals, Inc., in November 2009. From February 2002 until its acquisition by Ipsen, S.A., in October 2008, Dr. Scarlett served as founder, chief executive officer and a member of the board of directors of Tercica, Inc., and also as its president from February 2002 through February 2007. From March 1993 to May 2001, Dr. Scarlett served as president and chief executive officer of Sensus Drug Development Corporation. In 1995, he co-founded Covance Biotechnology Services, Inc., and served as a member of its board of directors from inception to 2000. From 1991 to 1993, Dr. Scarlett headed the North American Clinical Development Center and served as senior vice president of medical and scientific affairs at Novo Nordisk Pharmaceuticals, Inc. Dr. Scarlett holds a B.A. in chemistry from Earlham College and an M.D. from the University of Chicago, Pritzker School of Medicine.

Sean A. McCarthy, D. Phil.

President and Chief Executive Officer

Dr. McCarthy joined CytomX in December 2010 as our chief business officer and became a member of our board of directors and our president and chief executive officer in August 2011. Dr. McCarthy has more than twenty years of experience in the biotechnology industry encompassing roles in R&D, business development, financing and general management. Following completion of his post-doctoral training at the DNAX Research Institute (now Merck Palo Alto), Dr. McCarthy held research leadership and program management roles at Millennium Pharmaceuticals where he managed biologics discovery programs. From Millennium, Dr. McCarthy joined SGX Pharmaceuticals, where he spearheaded a wide range of large pharma partnerships as vice president business development and helped drive a strategic reorientation of the company from a platform business model to product-focused oncology company, leading to a successful initial public offering in 2006. Immediately prior to joining CytomX, Dr. McCarthy was a transactional partner at Pappas Ventures from April 2006 to December 2010, where he was responsible for investments in therapeutic, medical device and molecular diagnostic companies. Dr. McCarthy is an author on multiple peer reviewed scientific publications, issued patents and filed patent applications. He received a B.Sc. in biochemistry and pharmacology at King’s College, University of London; an MBA from the Rady School of Management at the University of California San Diego; and a D.Phil. in cancer biology from St. John’s College, University of Oxford. Dr. McCarthy currently serves as a member of the Board of Directors of the California Life Sciences Association.

"One small step for CytomX, one huge step for mankind in the fight against cancer."

—Lori Carman