Archives

Pharmacodynamic and Pharmacokinetic Activity of CX-801, a Masked IFNα2b PROBODY® Cytokine, in Patients with Advanced Melanoma

Benjamin Povinelli, Shannon Tsai, Kakali Dhar, Cathrine Leonowens, Stuart Johnston, Olga Vasiljeva, Madan Paidhungat, Yu-Waye Chu, Marcia Belvin, John M. Kirkwood, Yana G. Najjar, Monika Vainorius, Dylan Daniel; Poster presented at the Society for Immunotherapy of Cancer 2025 Annual Meeting, November 5-9, National Harbor, MD

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CX-908, a PROBODY® T Cell Engager Targeting CDH3 and CD3, Induces Tumor Regressions and Improves the Therapeutic Window in Preclinical Studies

Erwan Le Scolan, Lauren Kadavy, Leila M. Boustany, Clayton White, Tiffany Tse, Sayantan Mitra, Nicole Lapuyade, Vijit Dalal, Kai-Wen Cheng, Anna F. Nguyen, Conner Bardine, Michael B. Winter, Vahideh Vakil, Sean McAllister, Robert T. Dunn, II, Vangipuram Rangan, Olga Vasiljeva, Madan Paidhungat, Marcia Belvin, Dylan Daniel; Poster presented at the Society for Immunotherapy of Cancer 2025 Annual Meeting, November 5-9, National Harbor, MD

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An mRNA-encoded masked IL-12 improves systemic tolerability while maintaining anti-tumor efficacy in preclinical studies

Kanchana Ravichandran, Erwan LeScolan, Na Cai, Bruce Howng, Robert Lau, Lisa Clark, Joshua Millet, Pankaj Kumar, Sushma Gurumurthy, Raghava Sriramaneni, Sean McAllister, Vangipuran Rangan, Olga Vasiljeva, Madan Paidhungat, Dylan Daniel, Marcia Belvin, Lin Guey. Presented at the American Association for Cancer Research Annual Meeting, April 28, 2025.

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Conditionally activated IFNa induces an inflammatory tumor microenvironment in preclinical models and increases efficacy in combination with checkpoint blockade

Benjamin Povinelli, Kamaljeet Kaur, Alexey Berezhnoy, Hsin Wang, Na Cai, Nicole Lapuyade, Carol LePage, Michael Winter, Olga Vasiljeva, Madan Paidhungat, Vangipuram Rangan, Erwan Le Scolan, Leila Boustany, Marcia Belvin and Dylan Daniel. Presented at SITC 2023, November 1-5, 2023, San Diego, CA.

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Leveraging Conditional Activation to Localize Antibody Drug Conjugates to the Tumor

Marcia Belvin Ph.D. Presented at World ADC, October 16-19, 2023, San Diego, California.

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Designing Conditionally Activated Probody® Cytokines to Localize Antitumor Activity to Cancers

Dylan Daniel, Ph.D., Presented at the American Association of Immunologists Annual Meeting, May 13, 2023.

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Results of a phase 2 study of praluzatamab ravtansine (CX-2009) in patients with advanced breast cancer (ABC)

Kathy Miller, Sara M. Tolaney, Leisha Emens, Sung-Bae Kim, Erika Hamilton, Cristina Saura, Lucia Sanz, Valentina Boni, Filipa Lynce, Juan M. Cejalvo, Jennifer A. Crozier, Shirley Wang, Shannon Tsai, Hojjat Bazzazi, Hirdesh Uppal, Alison Hannah, Sara Hurvitz. Poster presented at the San Antonio Breast Cancer Symposium®, December 6-10, 2022.

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CX-801, Conditionally Activatable Interferon-alpha 2b Improves Tolerability and Exhibits Preferential Activity in Tumors

Alexey Berezhnoy, Ph.D., Presented at the Society for Immunotherapy of Cancer’s 37th Annual Meeting (SITC 2022), November, 8th, 2022.

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Tailoring the Selection of Target, Payload, and Tumor Type to Maximize the Therapeutic Index of Conditionally Activated ADCs

Marcia Belvin, SVP, Head of Research

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Probody-Interferon-alpha 2b Combines Antitumor Activity with Improved Tolerability

Alexey Berezhnoy, Ph.D., Presented at the American Association for Cancer Research (AACR) Annual Meeting 2022, April 11th, 2022.

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