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QSP Model of a Masked Tumor-Activated Antibody Video Abstract

Video accompanying Stroh et al. “Quantitative Systems Pharmacology Model of a Masked, Tumor-Activated Antibody.” CPT Pharmacometrics Syst. Pharmacol. (2019). doi: 10.1002/psp4.12448

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Antibody prodrugs for cancer

Expert Opinion on Biological Therapy; Kavanaugh, W. Michael; Published Online December 2019.

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Nonclinical Development of Probody Drug Conjugates

Richardson, J. (2019, September) Nonclinical Development of Probody Drug Conjugates. Presented at the Charles River 25th Annual Biotech Symposium: Biotechnology-Derived Therapeutics Perspectives on Nonclinical Development. Carlsbad, CA.

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Designing In and Around Tolerability Considerations for Immunotherapy Combinations

Clinical Pharmacology & Therapeutics; Stroh, M.; April 2018.

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Quantitative Systems Pharmacology Model of a Masked, Tumor-Activated Antibody

CPT: Pharmacometrics and Systems Pharmacology; Stroh, M., et al; May 2019.

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CX-072, a PD-L1 Probody Therapeutic, as Monotherapy in Patients With Advanced Solid Tumors: Preliminary Results of PROCLAIM-CX-072

Aung Naing, Fiona Thistlethwaite, Alexander Spira, Javier Garcia-Corbacho, Manreet Randhawa, Ferry ALM Eskens, Greg Durm, Nataliya Uboha, Omid Hamid, Anthony El-Khoueiry, Vanessa Huels, Will Garner, Beverly Benson, Hendrik-Tobias Arkenau, Patricia LoRusso. Poster presented at ASCO 2019, May 31-June 4, Chicago, Illinois.

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Preliminary Results of PROCLAIM-CX-2009, a First-in-Human, Dose-Finding Study of the Probody™ Drug Conjugate CX-2009 in Patients With Advanced Solid Tumors

Funda Meric-Bernstam, Valentia Boni, Alexander Spira, Rachel E. Sanborn, Hendrik-Tobias Arkenau, Randy F. Sweis, Howard Burris, Rui Li, Pratigya Gautam, Sreeni Yalamanchili, Matthias Will, Joyce F. Liu, James J. Harding. Poster presented at AACR 2019, March 29-April 3, Atlanta, Georgia.

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A Probody™ Drug Conjugate Targeting CD166 (ALCAM) Enhances Preclinical Antitumor Activity of a Probody Therapeutic Targeting PD-1

Erwan Le Scolan, Tiffany Tse, Michael Krimm, Will Garner, Hikmat Assi, Jennifer Razo, Laurie Wong, Kenneth R. Wong, Victoria Singson, Jennifer Leong, Linnea Diep, Jennifer H. Richardson, Siew Schleyer, Dylan Daniel, Marcia Belvin, W. Michael Kavanaugh. Poster presented at AACR 2019, March 29-April 3, Atlanta, Georgia

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