CX-072 (PD-L1-targeting Probody therapeutic)

CX-072 is a PD-L1-targeting Probody therapeutic for the treatment of cancer, currently being evaluated in a Phase 1/2 clinical trial. The study is evaluating CX-072 as monotherapy and in combination with Yervoy® (ipilimumab) or Zelboraf® (vemurafenib) in patients with certain cancers.

Study Title: PROCLAIM-072: A Trial to Find Safe and Active Doses of an Investigational Drug CX-072 for Patients With Solid Tumors or Lymphomas

Purpose: The purpose of this first-in-human study of CX-072 is to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activity of CX-072 administered intravenously (IV) as a single agent or in combination with ipilimumab or vemurafenib in adult subjects with advanced or recurrent solid tumors or lymphomas.

Start Date: January 2017

Estimated enrollment: 150 patients

For patients interested in learning if you are eligible for the trial, please visit clinicaltrials.gov.

CX-2009 (CD166-Targeting Probody Drug Conjugate)

CX-2009 is a CD-166-targeting Probody drug conjugate for the treatment of select advanced cancers and is being studied in a Phase 1/2 clinical trial. The treatment is being evaluated as monotherapy in patients with non-small cell lung cancer, breast cancer, ovarian cancer, Endometrial cancer, cholangiocarcinoma (bile duct cancer), head and neck cancer, castration-resistant prostate cancer.

Study Title: PROCLAIM-CX-2009: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2009 for Patients With Selected Solid Tumor

Purpose: The purpose of this first-in-human study of CX-2009 is to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activity of CX-2009 in adult subjects with metastatic or locally advanced unresectable solid tumors. PROCLAIM: PRObody CLinical Assessment In Man CX-2009 clinical trial 001

Start Date: June 2017

Estimated enrollment: 150 patients

For patients interested in learning if you are eligible for the trial, please visit clinicaltrials.gov